Initiation of Globin Synthesis
نویسندگان
چکیده
منابع مشابه
Hemin Control of Globin Synthesis
Human mature erythrocyte postribosomal supernatant contains a hemin-reversible translational repressor of globin synthesis as measured in the rabbit reticulocyte cell-free system. Incubation of human supernatant minus hemin at 37” for 2 hours results in conversion of the repressor to a hemin-irreversible form. The presence of 35 pM hemin retards this conversion. Both hemin-reversible and -irrev...
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By PAUL HELLER, JOHN VAN STONE, DAVID APPLE AND RICHARD D. COLEMAN A RARE FORM of hereditary anemia characterized by hypochromia of the erythrocytes in tile presence of increased iron stores has been designated by Heilmeyer1’2 as “hereditary hypochromic sideroachrestic anemia.” Garby and his co-workers3 and Hei1meyer1’ ’ have suggested that in this disorder heme synthesis is disturbed possibly ...
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In five patients with sickle beta-thalassemia there was balanced alpha- and beta-globin synthesis in the bone marrow and decreased total beta-chain synthesis relative to that of alpha-chain in the peripheral blood. These findings are similar to those in patients with simple beta-thalassemia trait. Despite a range of hemoglobin concentrations from 6.8 to 12.5 g/100 ml in the patients with sickle...
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We have measured the kinetics of specific globin mRNA and Friend virus (FV) RNA synthesis by hybridization to immobilized cDNA after induction of differentiation of two erythroleukemia cell lines (F4N, BS) by butyrate and Me,SO. The induction with butyrate in these cell lines occurs very rapidly (16-24 h). Cell cycle analysis was made of the populations throughout induction by flow cytofluorome...
متن کاملGlobin synthesis on reticulocyte membrane-bound ribosomes.
Evidence is presented that indicates that greater than 95 % of the protein synthesized by intact rabbit reticulocytes is globin and that only globin nascent chains are found on the membrane-bound ribosomes from reticulocytes. This result conflicts with reports in the literature that approximately 14% of the protein synthesized by reticulocytes is non-globin and that 86% of the protein synthesiz...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1972
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)81113-2